Dataset Information

Determination of species-specific amino acid substitutions in proboscidean type I collagen

ABSTRACT: To establish marker peptides for discriminating among proboscidean species, we analyzed sequence variations in type I collagen from mammoth, African savanna elephant, African forest elephant, and Asian elephant.

ORGANISM(S): Loxodonta Cyclotis Mammuthus Primigenius Loxodonta Africana Elephas Maximus

SUBMITTER: Yuki Taga

PROVIDER: PXD070572 | JPOST Repository | Wed Apr 08 00:00:00 GMT+01:00 2026

REPOSITORIES: jPOST

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	African%20forest%20elephant-1.baf	Other
	African%20forest%20elephant-1.mgf	Mgf
	African%20forest%20elephant-2.baf	Other
	African%20forest%20elephant-2.mgf	Mgf
	African%20forest%20elephant-3.baf	Other

Items per page:

1 - 5 of 20

Publications

Species identification of elephant and mammoth ivory products by LC-MS analysis of type I collagen marker peptides with a microsampling technique.

Kumazawa Yuki Y Mizuno Kazunori K Taga Yuki Y

Talanta 20260402

Unlike the legal trade in ivory from extinct mammoths, the international trade in ivory from extant elephants is highly restricted. This regulatory difference has led to the fraudulent labeling of elephant ivory as mammoth ivory. Here, we developed an LC-MS method to discriminate between elephant and mammoth species based on interspecies differences in the amino acid sequence of type I collagen, a stable protein component of ivory. Our LC-MS/MS proteomic analysis conclusively determined that the ...[more]

PMID: 41946337

Similar Datasets

Project description:Background: Mortality from preeclampsia (PE) and PE-associated morbidities are 3-to 5-fold higher in persons of African ancestry than in those of Asian and European ancestries. The placenta is central to the etiology of PE. However, how and to what extent the placenta contributes to worse PE outcomes in persons of African ancestry is yet to be fully elucidated. Objective: We aimed to identify molecular pathways that are unique or enriched in placentas of parturient persons of African ancestry with PE with severe features (sPE) compared to those of Asian and European ancestry with sPE. Study design: Bulk RNA sequencing was performed on 50 placentas from parturient persons with sPE of African (n=9), Asian (n=18) and European (n=23) ancestries and 73 normotensive controls of African (n=9), Asian (n=15) and European (n=49) ancestries. Results: Metabolism, hormone regulation and hypoxia/angiogenesis genes, previously described to be upregulated in PE, including: LEP, PAPPA2, INHA, FSTL3, FLT1, PHYHIP and ENG, were upregulated in sPE across ancestries, with high expression of FSTL3 being additionally associated with intrauterine growth restriction (p<.0001). Notably, LEP, FLT1 and PHYHIP were more highly upregulated in sPE placentas from parturient persons of African versus Asian ancestry. Genes associated with allograft rejection and adaptive immune response were selectively upregulated in placentas from African ancestry parturitions and not in those of Asian and European ancestries. Among the allograft rejection/adaptive immune response genes, IL3RA was of particular interest because the patient with the highest placental IL3RA level, a woman of African ancestry with IL3RA levels 4.5-fold above the average for African ancestry parturitions with sPE, developed postpartum cardiomyopathy, and was the only patient out of 123, that developed this condition. Interestingly, the sPE patients of Asian and European ancestries with the highest IL3RA levels for their ancestries developed unexplained tachycardia peripartum, necessitating echocardiography in the European ancestry patient. The association between elevated placental IL3RA levels and unexplained tachycardia or peripartum cardiomyopathy was found to be significant in the 50 sPE patients (p=.0005). Conclusions: African ancestry parturitions are associated with higher placental upregulation of metabolism (LEP) and hypoxia/angiogenesis (FLT1) genes, and selective upregulation of allograft rejection/adaptive immune response genes, including IL3RA. High placental expression of IL3RA may predict worse maternal cardiovascular outcomes, including peripartum cardiomyopathy. Studies evaluating placental IL3RA levels in peripartum cardiomyopathy cohorts are therefore warranted, as are broader studies evaluating placental factors in maternal cardiovascular outcomes postpartum.