Screening pertactin-specific antibodies and evaluating competitive epitope recognition by native mass spectrometry

ABSTRACT: This study employs high-resolution native mass spectrometry (nMS) to define, compare, and mechanistically dissect the binding behavior of four therapeutic monoclonal antibodies (1E7, 2B1, 1F2, and 2E9) targeting the Bordetella pertussis antigen pertactin (Prn).

ORGANISM(S): Escherichia Coli Mus Musculus (mouse)

SUBMITTER: Jennifer S. Brodbelt 

PROVIDER: PXD071705 | JPOST Repository | Fri Feb 13 00:00:00 GMT 2026

REPOSITORIES: jPOST