Proteomics

Dataset Information

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Gauging Lipid Vulnerabilities in mRNA-LNPs Under Various Environmental Stressors Through TIMS-TOF Analysis


ABSTRACT: Mass spectrometry lipidomics dataset analyzing degradation pathways of ionizable lipids in mRNA lipid nanoparticles (LNPs) exposed to environmental stressors. UHPLC–TIMS-TOF MS was used to characterize lipid oxidation products and structural degradation of DLin-MC3-DMA (MC3), SM-102, and ALC-0315 under UV irradiation, oxidative conditions, thermal exposure, and freeze–thaw cycling.

ORGANISM(S): Cellular Organisms

SUBMITTER: Michael Girgis 

PROVIDER: PXD075449 | JPOST Repository | Mon Mar 16 00:00:00 GMT 2026

REPOSITORIES: jPOST

Dataset's files

Source:
Action DRS
GMU_ASMS_A0_1_2_3743.d.zip Other
GMU_ASMS_A0_1_3_3744.d.zip Other
GMU_ASMS_A1_2_1_3745.d.zip Other
GMU_ASMS_A1_2_2_3746.d.zip Other
GMU_ASMS_A1_2_3_3747.d.zip Other
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