Multiomics

Dataset Information

0

Sorafenib KINOMEscan-2


ABSTRACT: -

SUBMITTER: Mindy Davis 

PROVIDER: LDS-1173 | LINCS | 2016-06-03

REPOSITORIES: LINCS

Dataset's files

Source:
Action DRS
HMS_LINCS&file=LDS-1173.tar.gz Other
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Publications


We tested the interaction of 72 kinase inhibitors with 442 kinases covering >80% of the human catalytic protein kinome. Our data show that, as a class, type II inhibitors are more selective than type I inhibitors, but that there are important exceptions to this trend. The data further illustrate that selective inhibitors have been developed against the majority of kinases targeted by the compounds tested. Analysis of the interaction patterns reveals a class of 'group-selective' inhibitors broadl  ...[more]

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