Proteomics

Dataset Information

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Couzens_Hippo_P103_VS1_BioID


ABSTRACT:

PROVIDER: MSV000078460 | MassIVE | Thu Jul 04 00:00:00 BST 2013

REPOSITORIES: MassIVE

Dataset's files

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Couzens_Sup_Table_3_P103_VS1_June25_2013.xlsx Xlsx
README_Couzens_P103_VS1_Jun23_2013.docx Other
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Couzens_SAINTexpress_ForWeb_P103_VS1_May30.xlsx Xlsx
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Publications

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

Couzens Amber L AL   Knight James D R JD   Kean Michelle J MJ   Teo Guoci G   Weiss Alexander A   Dunham Wade H WH   Lin Zhen-Yuan ZY   Bagshaw Richard D RD   Sicheri Frank F   Pawson Tony T   Wrana Jeffrey L JL   Choi Hyungwon H   Gingras Anne-Claude AC  

Science signaling 20131119 302


The Hippo pathway regulates organ size and tissue homeostasis in response to multiple stimuli, including cell density and mechanotransduction. Pharmacological inhibition of phosphatases can also stimulate Hippo signaling in cell culture. We defined the Hippo protein-protein interaction network with and without inhibition of serine and threonine phosphatases by okadaic acid. We identified 749 protein interactions, including 599 previously unrecognized interactions, and demonstrated that several i  ...[more]

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