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PROVIDER: MSV000078460 | MassIVE | Thu Jul 04 00:00:00 BST 2013


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Couzens_Sup_Table_3_P103_VS1_June25_2013.xlsx Xlsx
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Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

Couzens Amber L AL   Knight James D R JD   Kean Michelle J MJ   Teo Guoci G   Weiss Alexander A   Dunham Wade H WH   Lin Zhen-Yuan ZY   Bagshaw Richard D RD   Sicheri Frank F   Pawson Tony T   Wrana Jeffrey L JL   Choi Hyungwon H   Gingras Anne-Claude AC  

Science signaling 20131119 302

The Hippo pathway regulates organ size and tissue homeostasis in response to multiple stimuli, including cell density and mechanotransduction. Pharmacological inhibition of phosphatases can also stimulate Hippo signaling in cell culture. We defined the Hippo protein-protein interaction network with and without inhibition of serine and threonine phosphatases by okadaic acid. We identified 749 protein interactions, including 599 previously unrecognized interactions, and demonstrated that several i  ...[more]

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