Dataset Information
Systematic Discovery of TLR Signaling Components Delineates Viral-Sensing Circuits.
Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA138967
PROVIDER: MSV000078507 | MassIVE | Tue Dec 10 11:58:00 GMT 2013
REPOSITORIES: MassIVE
Publications
Systematic discovery of TLR signaling components delineates viral-sensing circuits.
Cell 20111101 4
Deciphering the signaling networks that underlie normal and disease processes remains a major challenge. Here, we report the discovery of signaling components involved in the Toll-like receptor (TLR) response of immune dendritic cells (DCs), including a previously unkown pathway shared across mammalian antiviral responses. By combining transcriptional profiling, genetic and small-molecule perturbations, and phosphoproteomics, we uncover 35 signaling regulators, including 16 known regulators, inv ...[more]
