Dataset Information
Raj_nSR100_interactions_P36_V21_P105_V17
Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA246157
INSTRUMENT(S): TripleTOF 5600, LTQ
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090)
SUBMITTER: Anne-Claude Gingras
PROVIDER: MSV000078609 | MassIVE | Wed Apr 23 13:26:00 BST 2014
SECONDARY ACCESSION(S): PXD001308
REPOSITORIES: MassIVE
Publications
A global regulatory mechanism for activating an exon network required for neurogenesis.
Molecular cell 20140911 1
The vertebrate and neural-specific Ser/Arg (SR)-related protein nSR100/SRRM4 regulates an extensive program of alternative splicing with critical roles in nervous system development. However, the mechanism by which nSR100 controls its target exons is poorly understood. We demonstrate that nSR100-dependent neural exons are associated with a unique configuration of intronic cis-elements that promote rapid switch-like regulation during neurogenesis. A key feature of this configuration is the insert ...[more]
