Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA269250
INSTRUMENT(S): TripleTOF 5600
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: Anne-Claude Gingras
PROVIDER: MSV000078943 | MassIVE | Wed Nov 19 14:46:00 GMT 2014
REPOSITORIES: MassIVE
Feng Yunpeng Y Vlassis Arsenios A Roques Céline C Lalonde Marie-Eve ME González-Aguilera Cristina C Lambert Jean-Philippe JP Lee Sung-Bau SB Zhao Xiaobei X Alabert Constance C Johansen Jens V JV Paquet Eric E Yang Xiang-Jiao XJ Gingras Anne-Claude AC Côté Jacques J Groth Anja A
The EMBO journal 20151130 2
During DNA replication, thousands of replication origins are activated across the genome. Chromatin architecture contributes to origin specification and usage, yet it remains unclear which chromatin features impact on DNA replication. Here, we perform a RNAi screen for chromatin regulators implicated in replication control by measuring RPA accumulation upon replication stress. We identify six factors required for normal rates of DNA replication and characterize a function of the bromodomain and ...[more]