Proteomics

Dataset Information

0

Sensitive Biomarker Discovery in Plasma Yields Novel Candidates for Early Myocardial Injury

ABSTRACT:

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Steven A. Carr 

PROVIDER: MSV000079033 | MassIVE | Mon Feb 09 09:20:00 GMT 2015

REPOSITORIES: MassIVE

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Publications

Multiplexed, Quantitative Workflow for Sensitive Biomarker Discovery in Plasma Yields Novel Candidates for Early Myocardial Injury.

Keshishian Hasmik H   Burgess Michael W MW   Gillette Michael A MA   Mertins Philipp P   Clauser Karl R KR   Mani D R DR   Kuhn Eric W EW   Farrell Laurie A LA   Gerszten Robert E RE   Carr Steven A SA  

Molecular & cellular proteomics : MCP 20150227 9

We have developed a novel plasma protein analysis platform with optimized sample preparation, chromatography, and MS analysis protocols. The workflow, which utilizes chemical isobaric mass tag labeling for relative quantification of plasma proteins, achieves far greater depth of proteome detection and quantification while simultaneously having increased sample throughput than prior methods. We applied the new workflow to a time series of plasma samples from patients undergoing a therapeutic, "pl  ...[more]