HDX-MS of CHIP wt and K30A mutant

ABSTRACT: HDX-MS was used to establish that conformational-inhibition-signals extended from the TPR-domain to the U-box of CHIP. This underscores inter-domain allosteric regulation of CHIP by the core molecular chaperones. Defining the chaperone-associated TPR-domain of CHIP as a manager of inter-domain communication highlights the potential for scaffolding modules to regulate, as well as assemble, complexes that are fundamental to protein homeostatic control.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Kathryn L Ball 

PROVIDER: MSV000079205 | MassIVE | Thu Jul 30 22:34:00 BST 2015

SECONDARY ACCESSION(S): PXD003513

REPOSITORIES: MassIVE