Proteomics

Dataset Information

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Human EGFR AP-MS project

ABSTRACT: Mass spectrometry was applied to comprehensively analyze the phosphorylation, ubiquitination, and interactome of wild type and endocytosis-defective EGFR variants before and after internalization in response to EGF or stress.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Dr Mike Moran 

PROVIDER: MSV000079525 | MassIVE | Tue Feb 23 15:38:00 GMT 2016

SECONDARY ACCESSION(S): PXD000788

REPOSITORIES: MassIVE

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Publications

Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress.

Tong Jiefei J   Taylor Paul P   Moran Michael F MF  

Molecular & cellular proteomics : MCP 20140505 7

Aberrant expression, activation, and stabilization of epidermal growth factor receptor (EGFR) are causally associated with several human cancers. Post-translational modifications and protein-protein interactions directly modulate the signaling and trafficking of the EGFR. Activated EGFR is internalized by endocytosis and then either recycled back to the cell surface or degraded in the lysosome. EGFR internalization and recycling also occur in response to stresses that activate p38 MAP kinase. Ma  ...[more]