Proteomics

Dataset Information

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Global identification of biofilm-specific proteolysis in Candida albicans


ABSTRACT: The global extracellular protease substrate specificity of C. albicans under biofilm and planktonic (suspension) conditions was determined with a synthetic library of 14-mer peptide substrates using an approach termed Multiplex Substrate Profiling by Mass Spectrometry (MSP-MS). Shotgun proteomics analysis on conditioned media from C. albicans grown under biofilm and planktonic conditions was performed to identify the corresponding proteases.

INSTRUMENT(S): LTQ Orbitrap XL

ORGANISM(S): Candida Albicans (ncbitaxon:5476)

SUBMITTER: Clarissa J. Nobile 

PROVIDER: MSV000079564 | MassIVE | Wed Mar 09 15:40:00 GMT 2016

REPOSITORIES: MassIVE

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<h4>Unlabelled</h4>Candida albicans is a fungal species that is part of the normal human microbiota and also an opportunistic pathogen capable of causing mucosal and systemic infections. C. albicans cells proliferate in a planktonic (suspension) state, but they also form biofilms, organized and tightly packed communities of cells attached to a solid surface. Biofilms colonize many niches of the human body and persist on implanted medical devices, where they are a major source of new C. albicans  ...[more]

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