Dataset Information

The Pan-Human Library: A repository of assays to quantify 10 000 proteins by SWATH-MS / SWATH-MS validation data

ABSTRACT: The â??Pan-Human Libraryâ?? is a compendium of highly specific assays covering more than 10 000 human proteins and enabling their targeted analysis in SWATH-MS datasets acquired from research or clinical specimens. This dataset contains validation SWATH-MS data and OpenSWATH results of whole cell lysates of HeLa (guot_L130330_005_SW, guot_L130330_006_SW, guot_L130330_007_SW) and U2OS cells (gout_L130330_013_SW, gout_L130330_014_SW, gout_L130330_015_SW). Further, the combined assay library (phl004_s32.csv) and the sample-specific assay libraries (phl004_sshela_s32.csv, phl004_ssu2os.csv) used for the analysis are provided.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Dr Ruedi Aebersold

PROVIDER: MSV000079592 | MassIVE | Wed Mar 16 17:41:00 GMT 2016

SECONDARY ACCESSION(S): PXD000954

REPOSITORIES: MassIVE

ACCESS DATA

Publications

A repository of assays to quantify 10,000 human proteins by SWATH-MS.

Rosenberger George G Koh Ching Chiek CC Guo Tiannan T Röst Hannes L HL Kouvonen Petri P Collins Ben C BC Heusel Moritz M Liu Yansheng Y Caron Etienne E Vichalkovski Anton A Faini Marco M Schubert Olga T OT Faridi Pouya P Ebhardt H Alexander HA Matondo Mariette M Lam Henry H Bader Samuel L SL Campbell David S DS Deutsch Eric W EW Moritz Robert L RL Tate Stephen S Aebersold Ruedi R

Scientific data 20140916

Mass spectrometry is the method of choice for deep and reliable exploration of the (human) proteome. Targeted mass spectrometry reliably detects and quantifies pre-determined sets of proteins in a complex biological matrix and is used in studies that rely on the quantitatively accurate and reproducible measurement of proteins across multiple samples. It requires the one-time, a priori generation of a specific measurement assay for each targeted protein. SWATH-MS is a mass spectrometric method th ...[more]

PMID: 25977788

Similar Datasets

Project description:Gastric cancer (GC) heterogeneity between and within tumors represents a barrier to disease management. We generated a comprehensive single-cell atlas of GC comprising 31 primary gastric tumor samples representing clinical stages I-IV and histological subtypes. We identified 34 distinct cell-lineage states, related by developmental trajectories and previously unreported rare cell populations. Many lineage states exhibited a distinctive tumor-associated expression profile, each contributing individually to a combined tumor-wide molecular collage. We observed increased plasma cell proportions as a feature of diffuse-type tumors associated with epithelial-resident KLF2, and a stagewise accrual of novel cancer-associated fibroblast sub-populations marked by high INHBA and FAP co-expression. Our results provide a high-resolution molecular resource for GC translational studies, identifying intra- and inter-patient lineage-states across distinct GC subtypes. #### GEO title mapping with the ID in PMID:34642171 #### Manuscript_ID Primary_Tumor Primary_Normal Peritoneal_Tumor Peritoneal_Normal NGCII521 sample7.csv sample6.csv - - NGCII513 sample22.csv sample21.csv - - NGCII512 sample26.csv sample25.csv - - NGCII520 sample5.csv sample4.csv - - NGCII514 sample24.csv sample23.csv - - NGCII518 sample2.csv sample1.csv - - NGCII525 sample10.csv sample9.csv - - NGCII527 sample12.csv sample11.csv - - NGCII538 sample36.csv sample35.csv sample38.csv sample37.csv NGCII539 sample32.csv - - - NGCII529 sample13.csv - - - NGCII511 sample15.csv - - - NGCII498 sample18.csv - - - NGCII522 sample29.csv - - - NGCII499 sample16.csv - - - NGCII502 sample14.csv - - - NGCII509 sample17.csv - - - NGCII540 sample33.csv - - - NGCII541 sample34.csv - - - NGCII543 sample39.csv - - - NGCII510 sample27.csv - - - NGCII519 sample3.csv - - - NGCII531 sample28.csv - - - NGCII545 sample40.csv - - - NGCII533 sample30.csv - - - NGCII524 sample8.csv - - - NGCII536 - sample31.csv - - NGCII011 - - sample19.csv - NGCII015 - - sample20.csv -

Dataset Information

The Pan-Human Library: A repository of assays to quantify 10 000 proteins by SWATH-MS / SWATH-MS validation data

Publications

A repository of assays to quantify 10,000 human proteins by SWATH-MS.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure