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Comparative Proteomic Study of Entamoeba histolytica Trophozoites, Cysts, and Cyst-Like Structures

ABSTRACT: Proteomic comparison between trophozoites, cysts and cyst-like structures of Entamoeba histolytica

INSTRUMENT(S): Easy-nLC 1000 UHPLC system

ORGANISM(S): Entamoeba Histolytica (ncbitaxon:5759)

SUBMITTER: Dr. Brian M. Balgley

PROVIDER: MSV000079674 | MassIVE | Thu Apr 21 15:04:00 BST 2016

SECONDARY ACCESSION(S): PXD004030

REPOSITORIES: MassIVE

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Proteomic Study of Entamoeba histolytica Trophozoites, Cysts, and Cyst-Like Structures.

Luna-Nácar Milka M Navarrete-Perea José J Navarrete-Perea José J Moguel Bárbara B Bobes Raúl J RJ Laclette Juan P JP Carrero Julio C JC

PloS one 20160526 5

The cyst stage of Entamoeba histolytica is a promising therapeutic target against human amoebiasis. Our research team previously reported the production in vitro of Cyst-Like Structures (CLS) sharing structural features with cysts, including rounded shape, size reduction, multinucleation, and the formation of a chitin wall coupled to the overexpression of glucosamine 6-phosphate isomerase, the rate-limiting enzyme of the chitin synthesis pathway. A proteomic study of E. histolytica trophozoites, ...[more]

PMID: 27228164

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