Proteomics

Dataset Information

0

Breast cancer tumors


ABSTRACT: The project analyzed 88 breast cancer clinical samples, including lymph node negative and positive primary tumors, lymph node metastases, and healthy tissue as control. All samples were combined with a super-SILAC mix that served as an internal standard for quantification.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Dr Tamar Geiger 

PROVIDER: MSV000079830 | MassIVE | Thu Jun 16 21:47:00 BST 2016

SECONDARY ACCESSION(S): PXD000815

REPOSITORIES: MassIVE

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Publications

System-wide Clinical Proteomics of Breast Cancer Reveals Global Remodeling of Tissue Homeostasis.

Pozniak Yair Y   Balint-Lahat Nora N   Rudolph Jan Daniel JD   Lindskog Cecilia C   Katzir Rotem R   Avivi Camilla C   Pontén Fredrik F   Ruppin Eytan E   Barshack Iris I   Geiger Tamar T  

Cell systems 20160303 3


The genomic and transcriptomic landscapes of breast cancer have been extensively studied, but the proteomes of breast tumors are far less characterized. Here, we use high-resolution, high-accuracy mass spectrometry to perform a deep analysis of luminal-type breast cancer progression using clinical breast samples from primary tumors, matched lymph node metastases, and healthy breast epithelia. We used a super-SILAC mix to quantify over 10,000 proteins with high accuracy, enabling us to identify k  ...[more]

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