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IPRG2015

ABSTRACT: IPRG-2015 Study -Differential Abundance Analysis in Label-Free Quantitative Proteomics. This study of LC-MS/MS data analysis focuses on data processing and statistical assessment for relative protein-level quantification in label-free proteomics.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932)

SUBMITTER: ABRF IPRG2015

PROVIDER: MSV000079843 | MassIVE | Mon Jun 20 12:24:00 BST 2016

SECONDARY ACCESSION(S): PXD015300

REPOSITORIES: MassIVE

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Publications

ABRF Proteome Informatics Research Group (iPRG) 2015 Study: Detection of Differentially Abundant Proteins in Label-Free Quantitative LC-MS/MS Experiments.

Choi Meena M Eren-Dogu Zeynep F ZF Colangelo Christopher C Cottrell John J Hoopmann Michael R MR Kapp Eugene A EA Kim Sangtae S Lam Henry H Neubert Thomas A TA Palmblad Magnus M Phinney Brett S BS Weintraub Susan T ST MacLean Brendan B Vitek Olga O

Journal of proteome research 20170103 2

Detection of differentially abundant proteins in label-free quantitative shotgun liquid chromatography-tandem mass spectrometry (LC-MS/MS) experiments requires a series of computational steps that identify and quantify LC-MS features. It also requires statistical analyses that distinguish systematic changes in abundance between conditions from artifacts of biological and technical variation. The 2015 study of the Proteome Informatics Research Group (iPRG) of the Association of Biomolecular Resou ...[more]

PMID: 27990823

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