Hb Oxidation in stored RBCs and Vesicles

ABSTRACT: We used a state of the art proteomics workflow, based upon nano-UPLC-MS\MS and advanced database searching to identify oxidative modifications to functional residues of hemoglobin subunit beta . Progressive accumulation of oxidized residues in stored erythrocytes and selective removal in vesicles was observed, further substantiating the hypothesis about vesiculation as a self-protecting mechanism in aging erthrocytes.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Dr Angelo D'Alessandro 

PROVIDER: MSV000080222 | MassIVE | Tue Oct 04 13:51:00 BST 2016

SECONDARY ACCESSION(S): PXD002798

REPOSITORIES: MassIVE