Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Special interactions of Bacteroides fragilis toxin with outer membrane vesicles reveal new mechanism of its secretion and delivery

ABSTRACT: Here we present MS1 spectra of nontoxigenic and toxigenic BF cells membrane extract, complemented by MS/MS spectra of separate parent ions in positive and negative mode --------- MS1 total spectra BFplus and BFminus in negative and positive mode 2015-09-04-pos-bminus-baselinel-1.d - MS1 acquisition spectre of sample BFminus in pos mode, sample acquisition started from 7.5 min of chromatogramm 2015-09-04-pos-bminus-picture-tertac-dla lockmass.d - MS1 acquisition spectre of sample BFminus in pos mode, tetracycline as internal standard was used,m/z 445 NAT-neg-6-plus.d - MS1 acquisition spectre of sample BFplus in neg mode nat-plus-pos.d- MS1 acquisition spectre of sample BFplus in pos mode NAT-neg-2-minus-1-10.d - MS1 acquisition spectre of sample BFminus in neg mode

INSTRUMENT(S): maXis

ORGANISM(S): Bacteroides Fragilis 638r (ncbitaxon:862962)

SUBMITTER: Anna Vanyushkina, Daria Rakitina

PROVIDER: MSV000080382 | MassIVE | Wed Dec 07 04:25:00 GMT 2016

REPOSITORIES: MassIVE

ACCESS DATA

Json Xml

Similar Datasets

Comparative transcriptomics reveals circadian and pluripotency networks as two pillars of longevity regulation

Project description:Mammals differ more than 100-fold in maximum lifespan. Here, we conducted comparative transcriptomics on 26 species with diverse lifespans. We identified thousands of genes with expression levels negatively or positively correlated with a species' maximum lifespan (Neg- or Pos-MLS genes). Neg-MLS genes are primarily involved in energy metabolism and inflammation. Pos-MLS genes show enrichment in DNA repair, microtubule organization, and RNA transport. Expression of Neg- and Pos-MLS genes is modulated by interventions, including mTOR and PI3K inhibition. Regulatory networks analysis showed that Neg-MLS genes are under circadian regulation possibly to avoid persistent high expression, whereas Pos-MLS genes are targets of master pluripotency regulators OCT4 and NANOG and are upregulated during somatic cell reprogramming. Pos-MLS genes are highly expressed during embryogenesis but significantly downregulated after birth. This work provides targets for anti-aging interventions by defining pathways correlating with longevity across mammals and uncovering circadian and pluripotency networks as central regulators of longevity.

2022-05-18 | GSE190756 | GEO

Effect of loss of Gfi1b on hematopietic stem cells

Project description:Using Gfi1b conditional mice, deletion of gfi1b in the hematopietic system was induced by injecting MxCre tg Gfi1bfl/fl mice with pIpC. 30 days after injection, Cd150 pos, Cd 48 neg, Lin neg Sca and c-kit pos stem cells were sortrted from Gfi1bfl/fl and Mxcre tg Gfi1bfl/fl mice and analysed. We used the mouse Affymetrix Gene ST Array.

2010-09-03 | GSE20655 | GEO

Effect of loss of Gfi1b on hematopietic stem cells

2010-09-03 | E-GEOD-20655 | biostudies-arrayexpress

GNPS DOM LCMS Interlab Ring Trial - Lab 2

Project description:Lab 2 LCMS data set (pos and neg, MS1 and MS2) for the 5 sample types in the interlab study. Note that some negative mode runs had faulty injections, leading to no sample being analysed.

2021-07-13 | MSV000087809 | GNPS

GNPS DOM LCMS Interlab Ring Trial - Lab 9

Project description:Lab 9 LCMS data set (pos and neg, MS1 and MS2) for the 5 sample types in the interlab study.

2021-07-22 | MSV000087863 | GNPS

Lipidomics data of cured COVID-19 patients

Project description:SE vs H and MY vs H data (neg & pos) for statistical analysis

2020-12-15 | PXD023154 | iProX

The MET oncogene is a functional marker of a glioblastoma stem cell subtype and drives the invasive phenotype

Project description:Eighteen independent neurospheres derived from patients affected by primary glioblastoma were grouped into “classical”, “mesenchymal” or “proneural” subtypes according to analysis of genetic lesions and gene expression profiling. Here we show that expression of the MET oncogene, encoding the tyrosine kinase receptor for HGF, associates with mesenchymal and proneural neurospheres (Met-pos-NS). Met expression is almost absent from classical neurospheres (Met-neg-NS), and mutually exclusive with amplification and expression of the EGF receptor gene. Met-pos-NS and Met-neg-NS display distinct growth factor requirements, differentiate along divergent pathways, and generate tumors with distinctive histological features. Met-pos-NS contain a variable percentage of Met positive (Methigh) and Met negative (Metneg) cells. After purification, only Methigh cells display clonogenic ability in vitro, and regenerate neurospheres containing both Methigh and Metneg cells. After in vivo transplantation, Methigh cells display highly enriched tumorigenic potential as compared with Metneg cells. At functional level, in Methigh cells, HGF concomitantly sustains proliferation, clonogenicity, expression of self-renewal markers, migration and invasion. These data show that Met is a functional marker of glioblastoma stem cells, and a candidate target for molecular diagnosis and therapy of a glioblastoma subset. 37 samples (17 replicate samples and 1 triplicate sample)

2012-10-05 | E-GEOD-36426 | biostudies-arrayexpress

Liver colonisation by colorectal cancer metastases requires YAP-controlled plasticity at the micrometastatic stage

Project description:Human engineered CRC organoids were equipped with the intestinal stem cell reporter STAR reflecting transcriptional activity of ASCL2. Successfully growing organoids display heterogeneous STAR expression and grow into big structures, while growth-compromised organoids stay small and are either entirely STAR-pos or STAR-neg.

2022-02-23 | GSE193248 | GEO

The MET oncogene is a functional marker of a glioblastoma stem cell subtype and drives the invasive phenotype

2012-10-05 | GSE36426 | GEO

Ac-IP tag enables multiplexed proteome quantification in data-independent acquisition mode

Project description:We propose the isotopically labeled Ac-IP (acetyl-isoleucine-proline) tag for multiplexed quantification of peptides at the MS1 level in the data-independent acquisition (DIA) mode. Differentially labeled peptides have distinct precursor ions carrying the quantitative information but identical MS2 spectra. The isotopically labeled Ac-Ile part leaves as a neutral loss upon collision-induced dissociation (CID) while fragmentation of the peptide backbone generates information for peptide identification.

2021-06-07 | PXD022606 | Pride

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data