Proteolytic processing of CD99

ABSTRACT: The adhesion molecule CD99 is essential for transendothelial migration (TEM) of leukocytes. Here we demonstrate by biochemical and cellular assays that CD99 undergoes ectodomain shedding by the metalloprotease meprin ? and subsequent intramembrane proteolysis by ?-secretase. The cleavage site in CD99 was identified by mass spectrometry within an acidic region highly conserved through different vertebrate species.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Andreas Tholey  

PROVIDER: MSV000080746 | MassIVE | Wed Mar 29 05:11:00 BST 2017

SECONDARY ACCESSION(S): PXD005428

REPOSITORIES: MassIVE