Gamma ray irradiation of epithelial carcinoma cells under hypoxic conditions

ABSTRACT: We demonstrate for the first time that under hypoxic conditions, A431 epithelial carcinoma cells exhibit increased viability when exposed to low-dose ?-irradiation, indicating that radiotherapy can promote tumor cell survival when oxygen supply is limited. When assessed using iTRAQ quantitative proteomics and Western blotting, irradiated tumor cells were observed to significantly up-regulate the expression of calcium-binding proteins CALM1, CALU and RCN1, suggesting important roles for these mediators in promoting tumor cell survival during hypoxia.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Newman Sze  

PROVIDER: MSV000080784 | MassIVE | Wed Mar 29 14:36:00 BST 2017

SECONDARY ACCESSION(S): PXD003937

REPOSITORIES: MassIVE