Dataset Information

MDA-MB-231 Breast Cancer Bone Tropic vs Parental Hypoxic Secretome Analysis

ABSTRACT: The project profiled the expression patterns in hypoxia induced secretomes between MDA-MB-231 parental and MDA-MB-231 Bone Tropic (BT) breast cancer cell lines which have been previously generated by Massague and colleagues (Kang et al. Cancer Cell 2003).

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Janine T Erler

PROVIDER: MSV000080797 | MassIVE | Wed Mar 29 16:56:00 BST 2017

SECONDARY ACCESSION(S): PXD000397

REPOSITORIES: MassIVE

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Publications

The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase.

Cox Thomas R TR Rumney Robin M H RMH Schoof Erwin M EM Perryman Lara L Høye Anette M AM Agrawal Ankita A Bird Demelza D Latif Norain Ab NA Forrest Hamish H Evans Holly R HR Huggins Iain D ID Lang Georgina G Linding Rune R Gartland Alison A Erler Janine T JT

Nature 20150527 7554

Tumour metastasis is a complex process involving reciprocal interplay between cancer cells and host stroma at both primary and secondary sites, and is strongly influenced by microenvironmental factors such as hypoxia. Tumour-secreted proteins play a crucial role in these interactions and present strategic therapeutic potential. Metastasis of breast cancer to the bone affects approximately 85% of patients with advanced disease and renders them largely untreatable. Specifically, osteolytic bone le ...[more]

PMID: 26017313

Publication: 1/2

Dataset Information

MDA-MB-231 Breast Cancer Bone Tropic vs Parental Hypoxic Secretome Analysis

Publications

The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase.

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