Transcription factor-SNP interactome for colorectal cancer risk loci

ABSTRACT: A core task to understand the consequences of non-coding single nucleotide polymorphisms (SNP) is to identify their genotype specific binding of transcription factor (TF). Here, we generate a large-scale TF-SNP interaction map for a selection of 116 colorectal cancer (CRC) risk loci and validated TF binding to 10 putatively functional SNPs. Our data further revealed TF binding complexity adjacent to the 116 risk loci, adding an additional layer of understanding to regulatory networks associated with CRC relevant loci.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Ning Qing Liu  

PROVIDER: MSV000080810 | MassIVE | Thu Mar 30 14:52:00 BST 2017

SECONDARY ACCESSION(S): PXD004435

REPOSITORIES: MassIVE