Proteomics

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VEGF orchestration of the p130Cas Interactome

ABSTRACT: p130Cas is a polyvalent adapter protein essential for cardiovascular development, and with a key role in cell movement. In order to identify the pathways by which p130Cas exerts its biological functions in endothelial cells we mapped the p130Cas interactome and its dynamic changes in response to VEGF using high-resolution mass spectrometry and reconstruction of protein interaction (PPI) networks with the aid of multiple PPI databases. The work presented here was based on a collaboration between University College London and University College Dublin. Dr Ian Evans (first author) and Prof. Ian Zachary (lab head), can be contacted at: Centre for Cardiovascular Biology and Medicine, Division of Medicine The Rayne Building, University College London, London WC1E 6JJ, United Kingdom. Contact details for University College Dublin collaborators can be found below.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Walter Kolch  

PROVIDER: MSV000080860 | MassIVE | Sat Apr 01 00:44:00 BST 2017

SECONDARY ACCESSION(S): PXD003902

REPOSITORIES: MassIVE

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Publications

Vascular Endothelial Growth Factor (VEGF) Promotes Assembly of the p130Cas Interactome to Drive Endothelial Chemotactic Signaling and Angiogenesis.

Evans Ian M IM   Kennedy Susan A SA   Paliashvili Ketevan K   Santra Tapesh T   Yamaji Maiko M   Lovering Ruth C RC   Britton Gary G   Frankel Paul P   Kolch Walter W   Zachary Ian C IC  

Molecular & cellular proteomics : MCP 20161222 2

p130Cas is a polyvalent adapter protein essential for cardiovascular development, and with a key role in cell movement. In order to identify the pathways by which p130Cas exerts its biological functions in endothelial cells we mapped the p130Cas interactome and its dynamic changes in response to VEGF using high-resolution mass spectrometry and reconstruction of protein interaction (PPI) networks with the aid of multiple PPI databases. VEGF enriched the p130Cas interactome in proteins involved in  ...[more]

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