Human CSF peptidomics of gamma secretase inhibition

ABSTRACT: Fifteen human healthy volunteers, divided into three groups, received a single dose of placebo or either 140 mg or 280 mg of the ?-secretase inhibitor semagacestat (LY450139). Endogenous peptides in CSF, sampled prior to administration of the drug and at six subsequent time points, were analyzed by liquid chromatography coupled to mass spectrometry, using isobaric labeling based on the tandem mass tag approach for relative quantification.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Johan Gobom  

PROVIDER: MSV000080870 | MassIVE | Sat Apr 01 03:21:00 BST 2017

SECONDARY ACCESSION(S): PXD003075

REPOSITORIES: MassIVE