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Novel Sarcopenia-related Alterations in Sarcomeric Protein Post-translational Modifications in Skeletal Muscles Identified by Top-down Proteomics

ABSTRACT: Sarcopenia, the age-related loss of skeletal muscle mass and strength, is a significant cause of morbidity in the elderly and is a major burden on health care systems. Unfortunately, the underlying molecular mechanisms in sarcopenia remain poorly understood. Herein, we utilized top-down proteomics to elucidate sarcopenia-related changes in the fast- and slow-twitch skeletal muscles of aging rats with a focus on the sarcomeric proteome, which includes both myofilament and Z-disc proteins--the proteins that constitute the contractile apparatuses.

INSTRUMENT(S): impact

ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116)

SUBMITTER: Ying Ge

PROVIDER: MSV000081157 | MassIVE | Mon Jun 12 09:58:00 BST 2017

REPOSITORIES: MassIVE

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