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Youn_et_al_RNAbodies_SAINT3108

ABSTRACT: Youn et al. High-density proximity mapping reveals the subcellular organization of mRNA-associated granules and bodies (SAINTexpress 3108)

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Anne-Claude Gingras

PROVIDER: MSV000081419 | MassIVE | Mon Aug 07 08:30:00 BST 2017

REPOSITORIES: MassIVE

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High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies.

Youn Ji-Young JY Dunham Wade H WH Hong Seo Jung SJ Knight James D R JDR Bashkurov Mikhail M Chen Ginny I GI Bagci Halil H Rathod Bhavisha B MacLeod Graham G Eng Simon W M SWM Angers Stéphane S Morris Quaid Q Fabian Marc M Côté Jean-François JF Gingras Anne-Claude AC

Molecular cell 20180125 3

mRNA processing, transport, translation, and ultimately degradation involve a series of dedicated protein complexes that often assemble into large membraneless structures such as stress granules (SGs) and processing bodies (PBs). Here, systematic in vivo proximity-dependent biotinylation (BioID) analysis of 119 human proteins associated with different aspects of mRNA biology uncovers 7424 unique proximity interactions with 1,792 proteins. Classical bait-prey analysis reveals connections of hundr ...[more]

PMID: 29395067

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