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Critical Period Inhibition of NKCC1 Rectifies Synapse Development and Restores Adult Tactile Response Maps in Fragile X Mice

ABSTRACT: Qionger He1, Erica D Arroyo2, Samuel N Smukowski3, Jian Xu, Claire Piochon1, Jeffrey N Savas3, Carlos Portera-Cailliau2 and Anis Contractor1,4* 1Department of Physiology & 3Department of Neurology, Northwestern University Feinberg School of Medicine; 2Departments of Neurology and Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 & 4Department of Neurobiology, Weinberg College of Arts and Sciences, Northwestern University, Chicago, IL 60611

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Jeffrey N. Savas, PhD

PROVIDER: MSV000081526 | MassIVE |

SECONDARY ACCESSION(S): PXD007736

REPOSITORIES: MassIVE

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Trans-kingdom mimicry underlies ribosome customization by a poxvirus kinase

Project description:Trans-kingdom mimicry underlies ribosome customization by a poxvirus kinase Sujata Jha*1, Madeline G. Rollins*1, Gabriele Fuchs2, Dean J. Procter1, Elizabeth A. Hall3, Kira Cozzolino3, Peter Sarnow4, Jeffrey N. Savas3 and Derek Walsh1 1Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. 2The RNA Institute, Department of Biological Sciences, University of Albany-SUNY, Albany, NY 12222, USA. 3Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. 4Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.

2017-03-21 | MSV000080661 | MassIVE

Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub

Project description:Authors: Marc P. Forrest1,2, Marc Dos Santos1,2, Nicolas H. Piguel1,2, Yi-Zhi Wang3, Nicole A. Hawkins4, Vikram A. Bagchi1,2, Leonardo E. Dionisio1,2, Sehyoun Yoon1,2, Dina Simkin3,4, Maria Dolores Martin-de-Saavedra1,2, Ruoqi Gao1,2, Katherine E. Horan1,2, Alfred L. George Jr.2,4, Mark S. LeDoux5,6, Jennifer A. Kearney 2,4, Jeffrey N. Savas2,3, Peter Penzes1,2* Affiliations: 1Department of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. 2Center for Autism and Neurodevelopment, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA 3Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. 4Department of Pharmacology Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. 5Department of Psychology, University of Memphis, Memphis, TN 38152, USA. 6Veracity Neuroscience LLC, Memphis, TN 38157, USA. *Correspondence to: p.penzes@northwestern.edu

2022-12-12 | MSV000090884 | MassIVE

VEGF orchestration of the p130Cas Interactome

Project description:p130Cas is a polyvalent adapter protein essential for cardiovascular development, and with a key role in cell movement. In order to identify the pathways by which p130Cas exerts its biological functions in endothelial cells we mapped the p130Cas interactome and its dynamic changes in response to VEGF using high-resolution mass spectrometry and reconstruction of protein interaction (PPI) networks with the aid of multiple PPI databases. The work presented here was based on a collaboration between University College London and University College Dublin. Dr Ian Evans (first author) and Prof. Ian Zachary (lab head), can be contacted at: Centre for Cardiovascular Biology and Medicine, Division of Medicine The Rayne Building, University College London, London WC1E 6JJ, United Kingdom. Contact details for University College Dublin collaborators can be found below.

2017-01-02 | PXD003902 | Pride

Acute ACAT1/SOAT1 blockade increases MAM cholesterol and strengthens ER-mitochondria connectivity

Project description:Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth College, Hanover NH;

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VEGF orchestration of the p130Cas Interactome

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Analysis of gastric microbiota by pyrosequencing in Korea

Project description:Sequencing of 16S ribosomal RNA (rRNA) gene, which has improved the characterization of microbial community, has made it possible to detect a low level Helicobacter pylori (HP) sequences even in HP-negative subjects which were determined by a combination of conventional methods. This study was conducted to obtain a cutoff value for HP colonization in gastric mucosa biopsies and gastric juices by the pyrosequencing method. Corresponding author: Nayoung Kim, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoungnam, Gyeonggi-do, Korea; Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea (Tel., +82-31-787-7008; e-mail, nayoungkim49@empas.com).

2014-09-18 | GSE61493 | GEO

Enterococcus faecalis reconfigure the activation of its transcriptional regulatory networks under different copper exposure levels

Project description:The microarrays experiments was performed with the purpose of identify transcriptional networks activated by copper. This experiment correspond the work tituled Enterococcus faecalis reconfigure the activation of its transcriptional regulatory networks under different copper exposure levels (work in preparation).Mauricio Latorrea,b, Jessica Galloway-Peñac,d,e, Jung Hyeo Rhoc,d, Marko Budinichf, Barbara E. Murrayc,d,e, Alejandro Maassb,f, Mauricio Gonzáleza,b,f*. a INTA, Laboratorio de Bioinformática y Expresión Génica, INTA, Universidad de Chile, Santiago, Chile. b Center for Genome Regulation (Fondap 15090007), University of Chile, Santiago, Chile. c Division of Infectious Disease, Department of Medicine, University of Texas Medical School, Houston, Texas, United States of America. d Center for the Study of Emerging and Reemerging Pathogens, University of Texas Medical School, Houston, Texas, United States of America. e Department of Microbiology and Molecular Genetics, University of Texas Medical School, Houston, Texas, United States of America f Mathomics, Center for Mathematical Modeling (UMI2807CNRS), Santiago, Chile. * Corresponding author. Address: El Líbano 5524, Santiago 11, Chile. Fax: +56 (2) 2214030.

2013-11-12 | GSE45131 | GEO

Comparison of whole brain expression data between selectively bred P and NP, alcohol naïve rats

Project description:Gene expression was analyzed in brains of 4 male selectively-bred alcohol-preferring (P) rats (generation 63) and 3 male alcohol non-preferring (NP) rats (generation 62) that were obtained from Dr. Richard L. Bell, Indiana University School of Medicine, Indianapolis, IN. These rats had never been exposed to alcohol.

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Mice obesity associated circulating sEVs proteomics

Project description:This animal study was approved by the Ethics Committee at school of Chinese medicine,Hong Kong Baptist University. A total of 4 female and 4 male C57BL/6 mices were included in control diet group (BC); A total of 4 female and 4 male C57BL/6 mices were included in high fat diet group (BT).

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Prinary breast cancers and brain metastasis

Project description:Sixteen paired matched samples from primary breast cancers and brain metastases diagnosed between April 1, 2001 and December 31, 2012 were collected from 8 institutions. Brain metastases were identified based on magnetic resonance imaging and/or computed tomography findings. The clinical characteristics of all the patients were obtained from their medical records. This study was approved by the institutional review board of each participating institute (Tokai University School of Medicine; National Hospital Organization Osaka National Hospital; Kinki University School of Medicine; Niigata Cancer Center Hospital; Shizuoka General Hospital; Hokkaido Cancer Center; National Hospital Organization, Tokyo Medical Center; and Gunma Prefectural Cancer Center). Matching primary breast cancers and brain metastases Formalin-Fixed Paraffin-Embedded (FFPE) specimens for gene expression analysis were collected into RNA. RNA from specimens was isolated, and quantity and quality of the each RNA was using an Agilent 2100 Bioanalyzer (Agilent Technologies). Genome-wide expression levels of transcripts were analyzed using the Affymetrix U133A gene chips (Affymetrix) according to the manufacture’s instructions.

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