Dataset Information


Identifying PTMs on PERIOD over a circadian day in Drosophila melanogaster

ABSTRACT: Circadian clocks coordinate time-of-day specific metabolic and physiological processes to maximize performance and fitness. In addition to light, which is considered the strongest time cue to entrain animal circadian clocks, metabolic input has emerged as an important signal for clock modulation and entrainment, especially in peripheral clocks. Circadian clock proteins have been to be substrates of O-GlcNAcylation, a nutrient sensitive post-translational modification (PTM), and the interplay between clock protein O-GlcNAcylation and other PTMs, like phosphorylation, is expected to facilitate the regulation of circadian physiology by metabolic signals. Here, we used mass spectrometry proteomics to identify PTMs on PERIOD, the key biochemical timer of the Drosophila clock, over the circadian cycle.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Drosophila melanogaster  

SUBMITTER: Joanna Chiu  

PROVIDER: MSV000081736 | MassIVE | Thu Nov 23 14:25:00 GMT 2017



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