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Pervasive, coordinated protein level changes driven by transcript isoform switching during meiosis in yeast

ABSTRACT: To better understand the gene regulatory mechanisms that program developmental processes, we carried out simultaneous, genome-wide measurements of mRNA, translation and protein through meiotic differentiation in budding yeast.

OTHER RELATED OMICS DATASETS IN: PRJNA428526

INSTRUMENT(S): Q Exactive

ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932)

SUBMITTER: Marko Jovanovic

PROVIDER: MSV000081874 | MassIVE | Tue Jan 02 17:13:00 GMT 2018

REPOSITORIES: MassIVE

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Precise Post-translational Tuning Occurs for Most Protein Complex Components during Meiosis.

Eisenberg Amy Rose AR Higdon Andrea A Keskin Abdurrahman A Hodapp Stefanie S Jovanovic Marko M Brar Gloria Ann GA

Cell reports 20181201 13

Protein degradation is known to be a key component of expression regulation for individual genes, but its global impact on gene expression has been difficult to determine. We analyzed a parallel gene expression dataset of yeast meiotic differentiation, identifying instances of coordinated protein-level decreases to identify new cases of regulated meiotic protein degradation, including of ribosomes and targets of the meiosis-specific anaphase-promoting complex adaptor Ama1. Comparison of protein ...[more]

PMID: 30590036

Publication: 1/2

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