Target Landscape of Clinical Kinase Inhibitors

ABSTRACT: Here, we provide a comprehensive overview of the selectivity profiles of 242 kinase inhibitors currently in clinical trials. We screened available inhibitors against human protein kinases by using the Kinobead technology resulting in a drug matrix identifying the druggable kinome and related proteins.

INSTRUMENT(S): Orbitrap Fusion, Q Exactive HF, LTQ Orbitrap Elite, Q Exactive

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Bernhard Kuster  

PROVIDER: MSV000081932 | MassIVE | Fri Jan 12 21:28:00 GMT 2018

SECONDARY ACCESSION(S): PXD005336

REPOSITORIES: MassIVE