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Mining waste streams of food production for bioactive plant polysaccharides that affect the fitness and expressed activities of targeted human gut microbes

ABSTRACT: Mining waste streams of food production for bioactive plant polysaccharides that affect the fitness and expressed activities of targeted human gut microbes

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Microbiota (ncbitaxon:13613) Mus Musculus (ncbitaxon:10090)

SUBMITTER: Richard J. Giannone Robert L. Hettich

PROVIDER: MSV000082287 | MassIVE | Wed Apr 18 15:03:00 BST 2018

SECONDARY ACCESSION(S): PXD009535

REPOSITORIES: MassIVE

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Interspecies Competition Impacts Targeted Manipulation of Human Gut Bacteria by Fiber-Derived Glycans.

Patnode Michael L ML Beller Zachary W ZW Han Nathan D ND Cheng Jiye J Peters Samantha L SL Terrapon Nicolas N Henrissat Bernard B Le Gall Sophie S Saulnier Luc L Hayashi David K DK Meynier Alexandra A Vinoy Sophie S Giannone Richard J RJ Hettich Robert L RL Gordon Jeffrey I JI

Cell 20190901 1

Development of microbiota-directed foods (MDFs) that selectively increase the abundance of beneficial human gut microbes, and their expressed functions, requires knowledge of both the bioactive components of MDFs and the mechanisms underlying microbe-microbe interactions. Here, gnotobiotic mice were colonized with a defined consortium of human-gut-derived bacterial strains and fed different combinations of 34 food-grade fibers added to a representative low-fiber diet consumed in the United State ...[more]

PMID: 31539500

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