Dataset Information
DAP5 directs a widespread alternate form of cap-dependent mRNA translation initiation using eIF3d for specialized cell functions
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: 
Beatrix Ueberheide
PROVIDER: MSV000082407 | MassIVE | Fri May 25 15:33:00 BST 2018
SECONDARY ACCESSION(S): PXD009923
REPOSITORIES: MassIVE
Publications
A widespread alternate form of cap-dependent mRNA translation initiation.
Nature communications 20180803 1
Translation initiation of most mammalian mRNAs is mediated by a 5' cap structure that binds eukaryotic initiation factor 4E (eIF4E). However, inactivation of eIF4E does not impair translation of many capped mRNAs, suggesting an unknown alternate mechanism may exist for cap-dependent but eIF4E-independent translation. We show that DAP5, an eIF4GI homolog that lacks eIF4E binding, utilizes eIF3d to facilitate cap-dependent translation of approximately 20% of mRNAs. Genome-wide transcriptomic and t ...[more]
