Proteomics

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Delayed effect of early-life exposure to 17-alpha-ethinylestradiol on brain proteome of adult mangrove rivulus fish

ABSTRACT: PI: Experiments and fish exposures were performed in the laboratory of Frederic Silvestre at the University of Namur (Belgium). Proteomics contact: Proteomics sample preparation and biological mass spectrometry were performed in the laboratory of Prof. Dietmar Kueltz at UC Davis (CA). LC-MS/MS data obtained from brains of 17 adult mangrove rivulus exposed to different doses of 17-alpha-ethinylestradiol during early development.

INSTRUMENT(S): impact

ORGANISM(S): Kryptolebias Marmoratus (ncbitaxon:37003)

SUBMITTER: Frederic Silvestre   Dietmar Kueltz  

PROVIDER: MSV000082814 | MassIVE | Mon Aug 13 21:23:00 BST 2018

SECONDARY ACCESSION(S): PXD010764

REPOSITORIES: MassIVE

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Early-life exposure to the endocrine disruptor 17-α-ethinylestradiol induces delayed effects in adult brain, liver and ovotestis proteomes of a self-fertilizing fish.

Voisin Anne-Sophie AS   Kültz Dietmar D   Silvestre Frédéric F  

Journal of proteomics 20181212

Early-life represents a critically sensitive window to endocrine disrupting chemicals, potentially leading to long-term repercussions on the phenotype later in life. The mechanisms underlying this phenomenon, referred to as the Developmental Origins of Health and Disease (DOHaD), are still poorly understood. To gain molecular understanding of these effects, we exposed mangrove rivulus (Kryptolebias marmoratus) for 28 days post hatching (dph) to 4 and 120 ng/L 17-α-ethinylestradiol, a model xenoe  ...[more]

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