Thesaurus: quantifying phosphopeptide positional isomers

ABSTRACT: Raw DIA/DDA data to support Thesaurus manuscript. The human phosphorylation regulatory network represents a complex signaling cascade where proteins can be phosphorylated at multiple sites resulting in different functional states. Here we present Thesaurus, a hybrid search engine that detects, localizes, and quantifies novel positional isomers using site-specific fragment ions directly from data independent acquisition mass spectrometry experiments. This software works for several PTMs in addition to phosphorylation. Thesaurus is freely available from https://bitbucket.org/searleb/thesaurus

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Judit Villen   Brian Searle  

PROVIDER: MSV000082956 | MassIVE |

REPOSITORIES: MassIVE