Proteome changes during mouse brain aging
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (ncbitaxon:10090)
SUBMITTER: 
Jacek R Wisniewski
PROVIDER: MSV000082968 | MassIVE |
SECONDARY ACCESSION(S): PXD005230
REPOSITORIES: MassIVE
Publications
Global quantitative TPA-based proteomics of mouse brain structures reveals significant alterations in expression of proteins involved in neuronal plasticity during aging.
Duda Przemysław P Wójcicka Olga O Wiśniewski Jacek R JR Rakus Dariusz D
Aging 20180701 7
Aging is believed to be the result of alterations of protein expression and accumulation of changes in biomolecules. Although there are numerous reports demonstrating changes in protein expression in brain during aging, only few of them describe global changes at the protein level. Here, we present the deepest quantitative proteomic analysis of three brain regions, hippocampus, cortex and cerebellum, in mice aged 1 or 12 months, using the total protein approach technique. In all the brain region ...[more]
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Project description:Analysis of proteome changes during mouse brain aging
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Project description:Analysis of proteome changes during mouse brain aging
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