Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Uterine tubes

ABSTRACT: 1234567980 1234567980 1234567980 1234567980 1234567980 1234567980 1234567980

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Bos Taurus (ncbitaxon:9913)

SUBMITTER: Angela Mehta

PROVIDER: MSV000083397 | MassIVE | Mon Feb 04 03:16:00 GMT 2019

SECONDARY ACCESSION(S): PXD012597

REPOSITORIES: MassIVE

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

uterine microbiota

Project description:uterine microbiota Raw sequence reads

| PRJNA1116545 | ENA

Uterine microbiota

Project description:Uterine microbiota Metagenome

| PRJNA480713 | ENA

Uterine glands impact uterine receptivity, luminal fluid homeostasis and blastocyst implantation.

Project description: Not available

| S-EPMC5131473 | biostudies-literature

Uterine serous carcinoma.

Project description: Not available

| S-EPMC9445918 | biostudies-literature

Uterine epithelial ERα regulates preimplantation uterine luminal epithelial (LE) and uterine mRNAs

Project description:Uterine epithelial estrogen receptor α (ERα) deficiency in epiERα-/- (Esr1f/-Wnt7aCre/+) mice leads to dysregulated environment of uterine lumen, which is lined by uterine luminal epithelium (LE). We hypothesized that LE transcriptomes held molecular keys to understanding ERα in regulating preimplantation uterine environment. Day 0.5 post-coitum (D0.5) and D3.5 LE (isolated via enzymatic digestion), digested uterus (DU), and flash-frozen uterus (U) from Esr1f/- (control) and epiERα-/- mice were processed for mRNA-seq. There were minimal differentially expressed genes (DEGs, TPM>1, FC>2, FDR<0.05) between DU and U. Between D0.5 and D3.5 Esr1f/- LE, the top upregulated and downregulated GOBP pathways were on cellular processes and on innate immune responses, respectively, with the later also seen in Esr1f/- U. Compared to Esr1f/- LE, the most upregulated and downregulated pathways in D0.5 epiERα-/- LE were on innate immune responses and on biosynthesis and metabolism, respectively; while those in D3.5 epiERα-/- LE were on cell division and on signaling and metabolic processes, respectively. Na+ transmembrane transport was among shared upregulated pathways in D0.5 and D3.5 epiERα-/- LE. Between Esr1f/- and epiERα-/-, most DEGs in U were also DEGs in LE, limited DEGs in U only with higher expression than in LE were related to immune responses, implicating potential paracrine effects of uterine epithelial ERα. Selected DEGs were verified by realtime PCR and immunohistochemistry. This mRNA-seq dataset provides molecular keys to understanding temporal (e.g., innate immunity) and constituent (e.g., uterine fluid movement) functions, and potential paracrine effects of uterine epithelial ERα in regulating the preimplantation uterine environment.

2025-12-01 | GSE311705 | GEO

Relaxin mediates uterine artery compliance during pregnancy and increases uterine blood flow.

Project description: Not available

| S-EPMC3448779 | biostudies-literature

Uterine Metabolomics Reveals Protection of Taohong Siwu Decoction Against Abnormal Uterine Bleeding.

Project description: Not available

| S-EPMC7518030 | biostudies-literature

HER2 Oncogene as Molecular Target in Uterine Serous Carcinoma and Uterine Carcinosarcoma.

Project description: Not available

| S-EPMC10452357 | biostudies-literature

Uterine adhesion: Is luteal phase prior to follicular phase in uterine adhesiolysis?

Project description: Not available