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Molecular characterization of the brain peri-infarct region after post-stroke MANF administration

ABSTRACT: Shotgun proteomics analysis of brain peri-infarct region from rats subjected to ischemic stroke and treated with AAV-MANF or a control AAV-eGFP, compared to each other and to rats subjected to a sham operation.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116)

SUBMITTER: Risto Kostiainen Mikko Airavaara

PROVIDER: MSV000083869 | MassIVE | Tue May 28 23:19:00 BST 2019

SECONDARY ACCESSION(S): PXD014051

REPOSITORIES: MassIVE

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Molecular profile of the rat peri-infarct region four days after stroke: Study with MANF.

Teppo Jaakko J Vaikkinen Anu A Stratoulias Vassilis V Mätlik Kert K Anttila Jenni E JE Smolander Olli-Pekka OP Pöhö Päivi P Harvey Brandon K BK Kostiainen Risto R Airavaara Mikko M

Experimental neurology 20200327

The peri-infarct region after ischemic stroke is the anatomical location for many of the endogenous recovery processes; however, -the molecular events in the peri-infarct region remain poorly characterized. In this study, we examine the molecular profile of the peri-infarct region on post-stroke day four, a time when reparative processes are ongoing. We used a multiomics approach, involving RNA sequencing, and mass spectrometry-based proteomics and metabolomics to characterize molecular changes ...[more]

PMID: 32229226

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