Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Organ proteomics of germ free and conventional mice

ABSTRACT: A proteomic dataset comparing organ tissue differences between germ-free mice to conventional mice. Additional files include supplementary tables for reanalysis.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: David Gonzalez

PROVIDER: MSV000083874 | MassIVE | Wed May 29 11:34:00 BST 2019

REPOSITORIES: MassIVE

ACCESS DATA

Json Xml

Similar Datasets

Germ-free versus conventional mouse terminal ileum

Project description:Transcriptomics (using DNA microarrays) was used to quantitatively compare the terminal ileum from conventional and germ-free mice (female and male; C57BL/10A and BALB/c strains).

2017-09-29 | GSE95650 | GEO

L cells transcriptional profiling from germ-free and conventional mice

Project description:L cells are one of enteroendocrine cells. To understand the role of gut microbiota in its regulation, germ-free and conventional reporter mouse strain was used to sort Lpos and Lneg populations using FACS. The cell population were sorted from both ileum and colon and were subjected to transcriptional profiling.

2018-02-21 | E-MTAB-6322 | biostudies-arrayexpress

Expression data from germ-free and conventional mice fed lard or fish oil for 11 weeks

2015-07-14 | GSE70922 | GEO

Expression data in liver from germ-free and conventional mice fed lard or fish oil for 11 weeks

2016-02-29 | GSE73195 | GEO

Expression data from germ-free and conventional mice fed lard or fish oil for 11 weeks

Project description:Dietary lipids and gut microbiota may both influence adipose tissue physiology. By feeding conventional and germ-free mice high fat diets with different lipid compositon we aimed to investigate how dietary lipids and the gut microbiota interact to influence inflammation and metabolism in epididymal adipiose tissue (EWAT) Wild-type C57Bl/6 male mice 11 weeks of age were fed isocaloric diets (45% kcal fat) with either menhaden fish oil (Research Diets, D05122102) or lard (Research Diets, D10011202) for 11 weeks. Epididymal WAT samples were harvested at the end of the experiment and analyzed by microarray.

2015-07-14 | E-GEOD-70922 | biostudies-arrayexpress

Expression data in liver from germ-free and conventional mice fed lard or fish oil for 11 weeks

Project description:Dietary lipids and gut microbiota may both influence adipose tissue physiology. By feeding conventional and germ-free mice high fat diets with different lipid compositon we aimed to investigate how dietary lipids and the gut microbiota interact to influence inflammation and metabolism in the liver Wild-type C57Bl/6 male mice 11 weeks of age were fed isocaloric diets (45% kcal fat) with either menhaden fish oil (Research Diets, D05122102) or lard (Research Diets, D10011202) for 11 weeks. Liver samples were harvested at the end of the experiment and analyzed by microarray.

2016-02-29 | E-GEOD-73195 | biostudies-arrayexpress

Comparison of gene expression in conventional and germ-free intestine

Project description:Comparison of gene expression in conventional and germ-free intestine

| PRJNA92817 | ENA

GNPS 3D Germ Free and Specific Pathogen Free Mice

Project description:A collection of metabolomes from organs of germ free and specific pathogen free mice.

2016-07-20 | MSV000079949 | GNPS

RNA-Seq Profiling of Intestinal Expression of Xenobiotic Processing Genes in Germ-Free Mice

Project description:This study aimed to quantify and compare the mRNA abundance of all major XPGs in liver and intestine between conventional (CV) and germ-free (GF) mice using RNA-Seq. The CV RNA-Seq data were previously uploaded to GEO database by the same research group (GSE79848). All CV and GF mice were age-matched, and were analyzed under the same conditions (diet, water, bedding, and animal facility).

2017-08-30 | GSE102867 | GEO

Aged gut microbiota contributes to systemical inflammaging after transfer to germ-free mice

Project description:Advanced age is associated with chronic low-grade inflammation, which is usually referred to as inflammaging. Elderly are also known to have an altered gut microbiota composition. However, whether inflammaging is a cause or consequence of an altered gut microbiota composition is not clear. In this study gut microbiota from young or old conventional mice was transferred to young germ-free mice. Four weeks after gut microbiota transfer immune cell populations in spleen, Peyer’s patches, and mesenteric lymph nodes from conventionalized germ-free mice were analyzed by flow cytometry. In addition, whole-genome gene expression in the ileum was analyzed by microarray. Gut microbiota composition of donor and recipient mice was analyzed with 16S rDNA sequencing. Here we show by transferring aged microbiota to young germ-free mice that certain bacterial species within the aged microbiota promote inflammaging. This effect was associated with lower levels of Akkermansia and higher levels of TM7 bacteria and Proteobacteria in the aged microbiota after transfer. The aged microbiota promoted inflammation in the small intestine in the germ-free mice and enhanced leakage of inflammatory bacterial components into the circulation was observed. Moreover, the aged microbiota promoted increased T cell activation in the systemic compartment. In conclusion, these data indicate that the gut microbiota from old mice contributes to inflammaging after transfer to young germ-free mice.

2018-02-14 | GSE104063 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data