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Gut Microbial Ecosystem Multiomics in Inflammatory Bowel Disease

ABSTRACT: Using multiple omics approaches to explore the effect of the gut microbial ecosytem on inflammatory bowel disease

INSTRUMENT(S): Q Exactive

ORGANISM(S): Environmental Samples <bacteria> (ncbitaxon:48479)

SUBMITTER: Janet Jansson

PROVIDER: MSV000084050 | MassIVE | Tue Jul 02 14:00:00 BST 2019

SECONDARY ACCESSION(S): PXD008675

REPOSITORIES: MassIVE

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Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases.

Lloyd-Price Jason J Arze Cesar C Ananthakrishnan Ashwin N AN Schirmer Melanie M Avila-Pacheco Julian J Poon Tiffany W TW Andrews Elizabeth E Ajami Nadim J NJ Bonham Kevin S KS Brislawn Colin J CJ Casero David D Courtney Holly H Gonzalez Antonio A Graeber Thomas G TG Hall A Brantley AB Lake Kathleen K Landers Carol J CJ Mallick Himel H Plichta Damian R DR Prasad Mahadev M Rahnavard Gholamali G Sauk Jenny J Shungin Dmitry D Vázquez-Baeza Yoshiki Y White Richard A RA Braun Jonathan J Denson Lee A LA Jansson Janet K JK Knight Rob R Kugathasan Subra S McGovern Dermot P B DPB Petrosino Joseph F JF Stappenbeck Thaddeus S TS Winter Harland S HS Clish Clary B CB Franzosa Eric A EA Vlamakis Hera H Xavier Ramnik J RJ Huttenhower Curtis C

Nature 20190529 7758

Inflammatory bowel diseases, which include Crohn's disease and ulcerative colitis, affect several million individuals worldwide. Crohn's disease and ulcerative colitis are complex diseases that are heterogeneous at the clinical, immunological, molecular, genetic, and microbial levels. Individual contributing factors have been the focus of extensive research. As part of the Integrative Human Microbiome Project (HMP2 or iHMP), we followed 132 subjects for one year each to generate integrated longi ...[more]

PMID: 31142855

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