Sustained Reprioritization of metabolic pathways is associated with persistence and biofilm formation in non-typeable Haemophilus influenzae

ABSTRACT: Nontypeable Haemophilus influenzae (NTHI) is an opportunistic pathogen that has an essential requirement for heme-iron acquisition and must overcome host nutritional immunity to survive and persist in the host. In this study we examine the metabolic contributions to persistence using the evolved NTHI strain, RM33. Quantitative analyses identified 29 proteins, 55 transcripts and 31 metabolites that significantly changed within in vitro biofilms formed by RM33.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Haemophilus Influenzae (ncbitaxon:727)

SUBMITTER: Dr. J. Will Thompson   Kevin M. Mason  

PROVIDER: MSV000084166 | MassIVE | Fri Aug 02 10:26:00 BST 2019

REPOSITORIES: MassIVE