Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Lung Spheroid Cell and Mesenchymal Stem Cell Exosome Proteome

ABSTRACT: Human lung spheroid cell and human mesenchymal stem cell exosome proteome

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Michael Goshe

PROVIDER: MSV000084596 | MassIVE | Mon Nov 18 17:48:00 GMT 2019

REPOSITORIES: MassIVE

ACCESS DATA

Json Xml

Similar Datasets

Mesenchymal Stem Cell derived exosome induced changes in Breast Cancer Cells

Project description:Mesenchymal Stem Cell derived exosome induced changes in Breast Cancer Cells

| PRJNA631261 | ENA

Rosa Damascena Stem Cell-derived Exosome

Project description:Analysis of Rosa Damascena Stem Cell-derived Exosome

2023-08-21 | PXD043169 | Pride

Screening of Adipose mesenchymal stem cell derived secretome

Project description:The objective of this project is secreening the constituent of adipose derived mesenchymal stem cell secretome.

2023-09-11 | PXD045254 | iProX

Quantitative proteomics of matrix stiffness-induced immune regulation in human mesenchymal stem cell

Project description:Quantitative proteomics of matrix stiffness-induced immune regulation in human mesenchymal stem cells

2023-08-20 | PXD044670 | iProX

Comprehensive proteomic analysis of exosome mimetic vesicles and exosomes derived from human umbilical cord mesenchymal stem cells

Project description:Exosomes derived from mesenchymal stem cells (MSCs) have shown to have effective application prospects in the medical field, but exosome yield is very low. The production of exosome mimetic vesicles (EMVs) by continuous cell extrusion leads to more EMVs than exosomes, but whether the protein compositions of MSC-derived EMVs (MSC-EMVs) and exosomes (MSC-exosomes) are substantially different remains unknown. The purpose of this study was to conduct a comprehensive proteomic analysis of MSC-EMVs and MSC-exosomes and to simply explore the effects of exosomes and EMVs on wound healing ability. This study provides a theoretical basis for the application of EMVs and exosomes.In this study, EMVs from human umbilical cord MSCs (hUC MSCs) were isolated by continuous extrusion, and exosomes were identified after hUC MSC ultracentrifugation. A proteomic analysis was performed, and 2,315 proteins were identified. The effects of EMVs and exosomes on the proliferation, migration and angiogenesis of human umbilical vein endothelial cells (HUVECs) were evaluated by cell counting kit-8, scratch wound, Transwell and tubule formation assays. A mouse mode was used to evaluate the effects of EMVs and exosomes on wound healing . Bioinformatics analyses revealed that 1,669 proteins in both hUC MSC-EMVs and hUC MSC-exosomes play roles in retrograde vesicle-mediated transport and vesicle budding from the membrane. The 382 proteins unique to exosomes participate in extracellular matrix organization and extracellular structural organization, and the 264 proteins unique to EMVs target the cell membrane. EMVs and exosomes can promote wound healing and angiogenesis in mice and promote the proliferation, migration and angiogenesis of HUVECs.

2022-08-11 | PXD033899 | Pride

The RNA exosome nuclease complex regulates human embryonic stem cell differentiation

Project description:The RNA exosome nuclease complex regulates human embryonic stem cell differentiation

| PRJNA548151 | ENA

Twist1 regulates stem cell properties in mesenchymal stem cells

Project description:To investigate the function TWIST1 in the regulation of stemness in mesenchymal stem cell, we established human mesenchymal stem cell in TWIST1-overexpression.

2023-04-30 | GSE228776 | GEO

Twist1 regulates stem cell properties in mesenchymal stem cells

Project description:To investigate the function TWIST1 in the regulation of stemness in mesenchymal stem cell, we established human mesenchymal stem cell in TWIST1-overexpression.

2023-05-16 | GSE232324 | GEO

Valvular interstitial cells and mesenchymal stem cell proteomes

Project description:Proteome profiling of valvular disease driver cell populations and mesenchymal stem cells undergoing osteogenic differentiation.

2024-01-25 | PXD029949 | Pride

Human mesenchymal stem cell-derived matrices for enhanced osteoregeneration

Project description:Human mesenchymal stem cell-derived matrices for enhanced osteoregeneration

| PRJNA152309 | ENA