Proteomic and Transcriptomic Changes in Hibernating Grizzly Bears Reveal Metabolic and Signaling Pathways that Protect against Muscle Atrophy

ABSTRACT: Muscle atrophy is a physiological response to disuse and malnutrition, but hibernating bears are largely resistant to this phenomenon. Unlike other mammals, they efficiently reabsorb amino acids from urine, periodically activate muscle contraction, and their adipocytes differentially responds to insulin. The contribution of myocytes to the reduced atrophy remains largely unknown. Here we show how metabolism and atrophy signaling are regulated in skeletal muscle of hibernating grizzly bear.

OTHER RELATED OMICS DATASETS IN: GSE62812

INSTRUMENT(S): LTQ FT

ORGANISM(S): Ursus Arctos Horribilis (ncbitaxon:116960)

SUBMITTER: Prof. Uwe Voelker  

PROVIDER: MSV000084760 | MassIVE | Mon Jan 06 08:56:00 GMT 2020

SECONDARY ACCESSION(S): PXD016974

REPOSITORIES: MassIVE