Proteomics

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Proteogenomics of High hyperdiploid childhood acute lymphoblastic leukemia

ABSTRACT: Proteogenomic analysis and genomic profiling, RNA-sequencing, and mass spectrometry-based analysis of High hyperdiploid childhood acute lymphoblastic leukemia.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Janne Lehti??  

PROVIDER: MSV000084862 | MassIVE | Wed Jan 29 22:39:00 GMT 2020

SECONDARY ACCESSION(S): PXD010175

REPOSITORIES: MassIVE

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Publications

Hyperdiploidy, i.e. gain of whole chromosomes, is one of the most common genetic features of childhood acute lymphoblastic leukemia (ALL), but its pathogenetic impact is poorly understood. Here, we report a proteogenomic analysis on matched datasets from genomic profiling, RNA-sequencing, and mass spectrometry-based analysis of >8,000 genes and proteins as well as Hi-C of primary patient samples from hyperdiploid and ETV6/RUNX1-positive pediatric ALL. We show that CTCF and cohesin, which are mas  ...[more]

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