Quantitative proteomics links the LRRC59 interactome to mRNA translation on the ER membrane

ABSTRACT: Hannigan et al. characterize the protein interactomes of four ER ribosome-binding proteins using TMT-based proteomics, providing evidence that ER-bound ribosomes reside in distinct molecular environments. Their data link SEC62 to ER redox regulation and chaperone trafficking, and suggest a role for LRRC59 in SRP-coupled protein synthesis.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Dr. J. Will Thompson   Dr. Christopher Nicchitta  

PROVIDER: MSV000085009 | MassIVE | Tue Feb 25 14:52:00 GMT 2020

REPOSITORIES: MassIVE