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Proteomic Mapping of multifunctional complexes in triatomine Saliva

ABSTRACT: Salivary multiprotein complexes from Triatoma infestans, Triatoma dimidiata, Dipetalogaster maxima, Rhodnius prolixus, and Rhodnius neglectus were identified by Blue-Native-PAGE (BN-PAGE) coupled with liquid chromatography tandem mass spectrometry.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Triatominae (ncbitaxon:70999)

SUBMITTER: paula beatriz Santiago Jaime Martins de Santana Sebastien Charneau Carla Nunes de Araujo

PROVIDER: MSV000085118 | MassIVE | Wed Mar 18 18:56:00 GMT 2020

SECONDARY ACCESSION(S): PXD018101

REPOSITORIES: MassIVE

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Proteomic Mapping of Multifunctional Complexes Within Triatomine Saliva.

Santiago Paula Beatriz PB Charneau Sébastien S Mandacaru Samuel Coelho SC Bentes Kaio Luís da Silva KLDS Bastos Izabela Marques Dourado IMD de Sousa Marcelo Valle MV Ricart Carlos André O CAO de Araújo Carla Nunes CN Santana Jaime Martins JM

Frontiers in cellular and infection microbiology 20200902

Triatomines are hematophagous insects that transmit <i>Trypanosoma cruzi</i>, the etiological agent of Chagas disease. This neglected tropical disease represents a global health issue as it is spreading worldwide. The saliva of Triatominae contains miscellaneous proteins crucial for blood feeding acquisition, counteracting host's hemostasis while performing vasodilatory, anti-platelet and anti-coagulant activities, besides modulating inflammation and immune responses. Since a set of biological p ...[more]

PMID: 32984079

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