Defective insulin receptor signaling in hPSCs skews pluripotency and negatively perturbs neural differentiation

ABSTRACT: Proteomics and phosphoproteomics analyses of two human pluripotent stem cell (hPSC) lines with stable insulin receptor knock down. 6-plex TMT-based strategy was applied to compare control versus insulin receptor (IR) knockdown (n=3 replicates for each condition) for each cell lines (CHB8 and H9). Data was searched with MS-GF+ using PNNL's DMS Processing pipeline.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Wei-Jun Qian  

PROVIDER: MSV000085298 | MassIVE | Thu Apr 16 18:10:00 BST 2020

SECONDARY ACCESSION(S): PXD018606

REPOSITORIES: MassIVE