Dataset Information
Membrane-Based Affinity Purification to Identify Target Proteins of a Small-Molecule Drug
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: 
Liu Yang
PROVIDER: MSV000085483 | MassIVE | Wed May 27 19:51:00 BST 2020
SECONDARY ACCESSION(S): PXD019432
REPOSITORIES: MassIVE
Publications
Membrane-Based Affinity Purification to Identify Target Proteins of a Small-Molecule Drug.
Analytical chemistry 20200811 17
Identifying the target proteins of small-molecule drug candidates is important for determining their molecular mechanisms of action. Porous membranes derivatized with such small molecules may provide an attractive target-identification platform due to a high protein-capture efficiency during flow through membrane pores. This work employs carbonic anhydrase II (CAII) binding to immobilized 4-(2-aminoethyl)benzenesulfonamide (AEBSA) to examine the efficiency and selectivity of affinity capture in ...[more]
