Proteomic assessment of serum biomarkers of longevity in older men

ABSTRACT: We utilized a high throughput discovery-based proteomics platform to identify serum peptides and proteins that were associated with the attainment of longevity in a longitudinal study of community-dwelling men age 65 years or older. Baseline serum in 1196 men were analyzed using liquid chromatography-ion mobility-mass spectrometry, and lifespan was determined during ~12 years of follow-up. Men who achieved longevity (>90% expected survival) were compared to those who died earlier.

INSTRUMENT(S): LTQ Orbitrap XL

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Eric Orwoll  

PROVIDER: MSV000085611 | MassIVE | Fri Jun 19 00:00:00 BST 2020

REPOSITORIES: MassIVE