Proteomics

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Exploring the Sexual Dimorphism of Crustacean Neuropeptide Expression using Callinectus sapidus as a Model Organism


ABSTRACT: The impact of numerous diseases has been linked to differences in sex between organisms, including various neurological diseases. As neuropeptides are known to be key players in the nervous system, studying the variation of neuropeptidomic profiles between males and females in a crustacean model organism is of interest. By using high-resolution mass spectrometry with two complementary ionization sources in conjunction with quantitative chemical labeling, differences were observed in 5 key neural tissues and hemolymph.

INSTRUMENT(S): MALDI LTQ Orbitrap, Q Exactive HF

ORGANISM(S): Callinectes Sapidus (ncbitaxon:6763)

SUBMITTER: Lingjun Li  

PROVIDER: MSV000085694 | MassIVE | Sun Jul 05 20:41:00 BST 2020

REPOSITORIES: MassIVE

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Exploring the Sexual Dimorphism of Crustacean Neuropeptide Expression Using <i>Callinectes sapidus</i> as a Model Organism.

Hu Mengzhou M   Helfenbein Kylie K   Buchberger Amanda R AR   DeLaney Kellen K   Liu Yang Y   Li Lingjun L  

Journal of proteome research 20210419 5


The impact of numerous diseases has been linked to differences in sex between organisms, including various neurological diseases. As neuropeptides are known to be key players in the nervous system, studying the variation of neuropeptidomic profiles between males and females in a crustacean model organism is of interest. By using high-resolution mass spectrometry with two complementary ionization sources in conjunction with quantitative chemical labeling (isotopic reductive dimethylation), differ  ...[more]

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