Quantitative Proteomics of the Cancer Cell Line Encyclopedia
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos, Orbitrap Fusion
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: 
Steven P Gygi
PROVIDER: MSV000085836 | MassIVE | Mon Jul 27 18:01:00 BST 2020
REPOSITORIES: MassIVE
Publications
Quantitative Proteomics of the Cancer Cell Line Encyclopedia.
Nusinow David P DP Szpyt John J Ghandi Mahmoud M Rose Christopher M CM McDonald E Robert ER Kalocsay Marian M Jané-Valbuena Judit J Gelfand Ellen E Schweppe Devin K DK Jedrychowski Mark M Golji Javad J Porter Dale A DA Rejtar Tomas T Wang Y Karen YK Kryukov Gregory V GV Stegmeier Frank F Erickson Brian K BK Garraway Levi A LA Sellers William R WR Gygi Steven P SP
Cell 20200101 2
Proteins are essential agents of biological processes. To date, large-scale profiling of cell line collections including the Cancer Cell Line Encyclopedia (CCLE) has focused primarily on genetic information whereas deep interrogation of the proteome has remained out of reach. Here, we expand the CCLE through quantitative profiling of thousands of proteins by mass spectrometry across 375 cell lines from diverse lineages to reveal information undiscovered by DNA and RNA methods. We observe unexpec ...[more]
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